Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

ABSTRACT Leishmaniasis, a category I neglected tropical disease, is a group of diseases caused by the protozoan parasite Leishmania species with a wide range of clinical manifestations. Current treatment options can be highly toxic and expensive, with drug relapse and the emergence of resistance. Ba...

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Bibliographic Details
Main Authors: Hannah N. Corman, Jessica N. Ross, Francisco R. Fields, Douglas A. Shoue, Mary Ann McDowell, Shaun W. Lee
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
AS-48
Leishmania
antileishmanial
antimicrobial peptides
antiparasitic agents
bacteriocins
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02658-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02658-22

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