Rapid temporal control of Foxp3 protein degradation by sirtuin-1.

Rapid temporal control of Foxp3 protein degradation by sirtuin-1.

Maintenance of Foxp3 protein expression in regulatory T cells (Treg) is crucial for a balanced immune response. We have previously demonstrated that Foxp3 protein stability can be regulated through acetylation, however the specific mechanisms underlying this observation remain unclear. Here we demon...

Full description

Bibliographic Details
Main Authors: Jorg van Loosdregt, Diede Brunen, Veerle Fleskens, Cornelieke E G M Pals, Eric W F Lam, Paul J Coffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21533107/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21533107/pdf/?tool=EBI

Similar Items