DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD DETERMINATION OF ZIDOVUDINE ENCAPSULATED IN PCL NANOPARTICLES

DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD DETERMINATION OF ZIDOVUDINE ENCAPSULATED IN PCL NANOPARTICLES

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A reversed-phase high-performance liquid chromatographic (HPLC) method was developed and validated for the determination of encapsulation efficiency of zidovudine in nanoparticules. The method was carried out in isocratic mode using 0.040M sodium acetate: methanol: acetonitrile: glacial acetic acid...

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Bibliographic Details
Main Authors: Milena Cristina Ribeiro Souza Magalhães, Alisson Samuel Portes Caldeira, Hanna de Sousa Rocha Almeida, Sílvia Ligório Fialho, Armando da Silva Cunha Junior
Format: Article
Language:English
Published: Universidade Federal do Rio Grande do Sul 2017-12-01
Series:Drug Analytical Research
Subjects:
zidovudine
nanoparticle
polycaprolactone
hplc
validation
Online Access:https://seer.ufrgs.br/dar/article/view/79216/46095

Internet

https://seer.ufrgs.br/dar/article/view/79216/46095

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