Weakening the IF2-fMet-tRNA Interaction Suppresses the Lethal Phenotype Caused by GTPase Inactivation

Weakening the IF2-fMet-tRNA Interaction Suppresses the Lethal Phenotype Caused by GTPase Inactivation

Substitution of the conserved Histidine 448 present in one of the three consensus elements characterizing the guanosine nucleotide binding domain (IF2 G2) of <i>Escherichia coli</i> translation initiation factor IF2 resulted in impaired ribosome-dependent GTPase activity which prevented...

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Bibliographic Details
Main Authors: Jerneja Tomsic, Enrico Caserta, Cynthia L. Pon, Claudio O. Gualerzi
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
bacterial translation initiation
initiation factor IF2
GTP hydrolysis
dominant lethal phenotype
lethality suppression
Online Access:https://www.mdpi.com/1422-0067/22/24/13238

Internet

https://www.mdpi.com/1422-0067/22/24/13238

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