PI3K/Akt inhibition and down-regulation of BCRP re-sensitize MCF7 breast cancer cell line to mitoxantrone chemotherapy

PI3K/Akt inhibition and down-regulation of BCRP re-sensitize MCF7 breast cancer cell line to mitoxantrone chemotherapy

Objective(s):Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore,...

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Bibliographic Details
Main Authors: Tahereh Komeili-Movahhed, Shamileh Fouladdel, Elmira Barzegar, Shekoufeh Atashpour, Mohammad Hossein Ghahremani, Seyed Nasser Ostad, Zahra Madjd, Ebrahim Azizi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2015-05-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Breast cancer
BCRP
Combination therapy
Mitoxantrone
PI3K/Akt
siRNA
Online Access:http://ijbms.mums.ac.ir/pdf_4410_7e6d4a7a6fbb6fb16d249d55a5e3d5c6.html

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http://ijbms.mums.ac.ir/pdf_4410_7e6d4a7a6fbb6fb16d249d55a5e3d5c6.html

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