PI3K/Akt inhibition and down-regulation of BCRP re-sensitize MCF7 breast cancer cell line to mitoxantrone chemotherapy
Objective(s):Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore,...
Main Authors: | Tahereh Komeili-Movahhed, Shamileh Fouladdel, Elmira Barzegar, Shekoufeh Atashpour, Mohammad Hossein Ghahremani, Seyed Nasser Ostad, Zahra Madjd, Ebrahim Azizi |
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Format: | Article |
Language: | English |
Published: |
Mashhad University of Medical Sciences
2015-05-01
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Series: | Iranian Journal of Basic Medical Sciences |
Subjects: | |
Online Access: | http://ijbms.mums.ac.ir/pdf_4410_7e6d4a7a6fbb6fb16d249d55a5e3d5c6.html |
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