Alternative polyadenylation and dynamic 3′ UTR length is associated with polysome recruitment throughout the cardiomyogenic differentiation of hESCs

Alternative polyadenylation and dynamic 3′ UTR length is associated with polysome recruitment throughout the cardiomyogenic differentiation of hESCs

Alternative polyadenylation (APA) increases transcript diversity through the generation of isoforms with varying 3′ untranslated region (3′ UTR) lengths. As the 3′ UTR harbors regulatory element target sites, such as miRNAs or RNA-binding proteins, changes in this region can impact post-transcriptio...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Aruana F. F. Hansel-Frose, Jens Allmer, Marcel Friedrichs, Hellen Geremias dos Santos, Bruno Dallagiovanna, Lucía Spangenberg
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2024-02-01
Schriftenreihe:Frontiers in Molecular Biosciences
Schlagworte:
human embryonic stem cells
miRNA
polysome profiling
gene regulatory network
cardiomyocytes
cardiomyogenesis
Online Zugang:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1336336/full

Online

https://www.frontiersin.org/articles/10.3389/fmolb.2024.1336336/full

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