Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours

Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours

Abstract Background Natural killer (NK) cells play a critical role in cancer immunosurveillance. Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of activated NK cells from a small volume of peripheral blood. We tested the functionality of ex vivo expanded NK c...

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Bibliographic Details
Main Authors: Mira M. Shenouda, Amy Gillgrass, Tina Nham, Richard Hogg, Amanda J. Lee, Marianne V. Chew, Mahsa Shafaei, Craig Aarts, Dean A. Lee, John Hassell, Anita Bane, Sukhbinder Dhesy-Thind, Ali A. Ashkar
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Breast Cancer Research
Subjects:
Immunotherapy
PDX
NK cell expansion
NK cell therapy
Online Access:http://link.springer.com/article/10.1186/s13058-017-0867-9

Internet

http://link.springer.com/article/10.1186/s13058-017-0867-9

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