Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.

Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.

There is increasing evidence that deficient clearance of β-amyloid (Aβ) contributes to its accumulation in late-onset Alzheimer disease (AD). Several Aβ-degrading enzymes, including neprilysin (NEP), endothelin-converting enzyme (ECE) and angiotensin-converting enzyme (ACE) reduce Aβ levels and prot...

Full description

Bibliographic Details
Main Authors: James Scott Miners, Jen ePalmer, Hannah eTayler, Emma eAshby, Laura ePalmer, Patrick eKehoe, Seth eLove
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Cerebral Amyloid Angiopathy
Endothelin-1
Neprilysin
Alzheimer’s disease.
angiotensin-converting enzyme
cerebral hypoperfusion
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00238/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00238/full

Similar Items