LRG-1 promotes pancreatic cancer growth and metastasis via modulation of the EGFR/p38 signaling

LRG-1 promotes pancreatic cancer growth and metastasis via modulation of the EGFR/p38 signaling

Abstract Background The abnormal expression of leucine-rich-alpha-2-glycoprotein 1 (LRG-1) is reported to be associated with multiple malignancies, but its role in the progression of pancreatic ductal adenocarcinoma (PDAC) remains to be determined. Methods The expression of LRG-1 was assessed in PDA...

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Bibliographic Details
Main Authors: Zhi-Bo Xie, Yi-Fan Zhang, Chen Jin, Yi-Shen Mao, De-Liang Fu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
LRG-1
Pancreatic ductal adenocarcinoma
Epidermal growth factor receptor (EGFR)
p38
Biomarker
Online Access:http://link.springer.com/article/10.1186/s13046-019-1088-0

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