A novel NLRP3 inhibitor as a therapeutic agent against monosodium urate-induced gout

A novel NLRP3 inhibitor as a therapeutic agent against monosodium urate-induced gout

BackgroundSince NEK7 is critical for NLRP3 inflammasome activation, NEK7 inhibitors could be employed as therapeutic agents against gout, a representative disease caused by NLRP3 inflammasome.MethodsWe designed NEK7 inhibitors based on biochemical kinome profiling of 2,7-substituted thieno[3,2-d]pyr...

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Bibliographic Details
Main Authors: Kihyoun Park, Injae Shin, Yoonseon Kim, Hyereen Kang, Soo-Jin Oh, Eunkyeong Jang, Taebo Sim, Jeehee Youn, Myung-Shik Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
inflammasome
NEK7
gout
monosodium urate
crystal
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1307739/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1307739/full

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