Fluoxetine Promotes Hippocampal Oligodendrocyte Maturation and Delays Learning and Memory Decline in APP/PS1 Mice

Fluoxetine Promotes Hippocampal Oligodendrocyte Maturation and Delays Learning and Memory Decline in APP/PS1 Mice

Oligodendrogenesis dysfunction impairs memory consolidation in adult mice, and an oligodendrocyte abnormality is an important change occurring in Alzheimer's disease (AD). While fluoxetine (FLX) is known to delay memory decline in AD models, its effects on hippocampal oligodendrogenesis are unc...

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Bibliographic Details
Main Authors: Feng-lei Chao, Yi Zhang, Lei Zhang, Lin Jiang, Chun-ni Zhou, Jing Tang, Xin Liang, Jin-hua Fan, Xiao-yun Dou, Yong Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
oligodendrogenesis
oligodendrocytes
hippocampus
APP/PS1 transgenic mice
Alzheimer's disease
fluoxetine
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.627362/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2020.627362/full

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