A thermosensitive hydrogel-copper meta-organic framework composite improves hindlimb ischemia therapy through synergistically enhancing HIF-1α production and inhibiting HIF-1α degradation

A thermosensitive hydrogel-copper meta-organic framework composite improves hindlimb ischemia therapy through synergistically enhancing HIF-1α production and inhibiting HIF-1α degradation

Critical limb ischemia (CLI) remains a significant clinical challenge with high morbidity and mortality. Considering the critical role of hypoxia-inducible factor 1α (HIF-1α) in hypoxic site to induce angiogenesis by regulating the expression of growth factors, we prepared a cooperative composite (P...

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Bibliographic Details
Main Authors: Jinmei Cheng, Yushun Dou, Jiaxin Li, Tingting You, Yihai Wang, Mengchuan Wang, Shengjun Shi, Shenghui Peng, Chun-hui Cui, Xiaopin Duan, Jisheng Xiao
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Materials & Design
Subjects:
Critical limb ischemia
Copper metal–organic frameworks
Thermo-responsive hydrogel
HIF-1α induced angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127524000108

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http://www.sciencedirect.com/science/article/pii/S0264127524000108

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