Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.

Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.

The adipokine leptin realizes signal transduction via four different membrane-anchored leptin receptor (Ob-R) isoforms in humans. However, the amount of functionally active Ob-R is affected by constitutive shedding of the extracellular domain via a so far unknown mechanism. The product of the cleava...

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Bibliographic Details
Main Authors: Michael Schaab, Henriette Kausch, Juergen Klammt, Marcin Nowicki, Ulf Anderegg, Rolf Gebhardt, Stefan Rose-John, Juergen Scheller, Joachim Thiery, Juergen Kratzsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3335825?pdf=render

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http://europepmc.org/articles/PMC3335825?pdf=render

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