Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes

Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes

Fundamental questions about patient heterogeneity and human-specific pathophysiology currently obstruct progress towards a therapy for traumatic brain injury (TBI). Human in vitro models have the potential to address these questions. Three-dimensional spheroidal cell culture protocols for human-orig...

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Bibliographic Details
Main Authors: Aaron R. Shoemaker, Ian E. Jones, Kira D. Jeffris, Gina Gabrielli, Alyssa G. Togliatti, Rajeswari Pichika, Eric Martin, Evangelos Kiskinis, Colin K. Franz, John D. Finan
Format: Article
Language:English
Published: The Company of Biologists 2021-12-01
Series:Disease Models & Mechanisms
Subjects:
traumatic brain injury
human
in vitro
spheroid
Online Access:http://dmm.biologists.org/content/14/12/dmm048916

Internet

http://dmm.biologists.org/content/14/12/dmm048916

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