Evaluation of the immunogenicity and protective effects of a trivalent chimeric norovirus P particle immunogen displaying influenza HA2 from subtypes H1, H3 and B

Evaluation of the immunogenicity and protective effects of a trivalent chimeric norovirus P particle immunogen displaying influenza HA2 from subtypes H1, H3 and B

The ectodomain of the influenza A virus (IAV) hemagglutinin (HA) stem is highly conserved across strains and has shown promise as a universal influenza vaccine in a mouse model. In this study, potential B-cell epitopes were found through sequence alignment and epitope prediction in a stem fragment,...

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Bibliographic Details
Main Authors: Xin Gong, He Yin, Yuhua Shi, Xiaoqiu He, Yongjiao Yu, Shanshan Guan, Ziyu Kuai, Nasteha M Haji, Nafisa M Haji, Wei Kong, Yaming Shan
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:Emerging Microbes and Infections
Subjects:
influenza virus
hemagglutinin 2
trivalent chimeric immunogen
norovirus P particle
protective effects
Online Access:https://www.tandfonline.com/doi/10.1038/emi.2016.51

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https://www.tandfonline.com/doi/10.1038/emi.2016.51

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