New 5-Aryl-1,3,4-Thiadiazole-Based Anticancer Agents: Design, Synthesis, In Vitro Biological Evaluation and In Vivo Radioactive Tracing Studies

New 5-Aryl-1,3,4-Thiadiazole-Based Anticancer Agents: Design, Synthesis, In Vitro Biological Evaluation and In Vivo Radioactive Tracing Studies

A new series of 5-(4-chlorophenyl)-1,3,4-thiadiazole-based compounds featuring pyridinium (<b>3</b>), substituted piperazines (<b>4a–g</b>), benzyl piperidine (<b>4i</b>), and aryl aminothiazoles (<b>5a–e</b>) heterocycles were synthesized. Evaluation...

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Bibliographic Details
Main Authors: Rana M. El-Masry, Basma M. Essa, Adli A. Selim, Soad Z. El-Emam, Khaled O. Mohamed, Tamer M. Sakr, Hanan H. Kadry, Azza T. Taher, Sahar M. Abou-Seri
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceuticals
Subjects:
1,3,4-thiadiazole
anticancer activity
structure-activity relationship
radiolabeling
in vivo pharmacokinetics
Online Access:https://www.mdpi.com/1424-8247/15/12/1476

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https://www.mdpi.com/1424-8247/15/12/1476

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