Schistosome Sulfotransferases: Mode of Action, Expression and Localization

Schistosome Sulfotransferases: Mode of Action, Expression and Localization

Oxamniquine (OXA) is a prodrug activated by a sulfotransferase (<i>SULT</i>) that was only active against <i>Schistosoma mansoni</i>. We have reengineered OXA to be effective against <i>S. haematobium</i> and <i>S. japonicum</i>. Three derivatives stan...

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Bibliographic Details
Main Authors: Meghan A. Guzman, Anastasia Rugel, Sevan N. Alwan, Reid Tarpley, Alexander B. Taylor, Frédéric D. Chevalier, George R. Wendt, James J. Collins, Timothy J. C. Anderson, Stanton F. McHardy, Philip T. LoVerde
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
schistosomiasis
<i>Schistosoma mansoni</i>
<i>S. haematobium</i>
<i>S. japonicum</i>
oxamniquine derivatives
whole worm in situ hybridization
Online Access:https://www.mdpi.com/1999-4923/14/7/1416

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https://www.mdpi.com/1999-4923/14/7/1416

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