Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer

Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer

Although immune checkpoint inhibitors improved the clinical outcomes of advanced triple negative breast cancer (TBNC) patients, the response rate remains relatively low. Nigericin is an antibiotic derived from <i>Streptomyces hydrophobicus</i>. We found that nigericin caused cell death i...

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Bibliographic Details
Main Authors: Lisha Wu, Shoumin Bai, Jing Huang, Guohui Cui, Qingjian Li, Jingshu Wang, Xin Du, Wenkui Fu, Chuping Li, Wei Wei, Huan Lin, Man-Li Luo
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
nigericin
immune checkpoint inhibitor
pyroptosis
anti-tumor immune-response
triple-negative breast cancer
Online Access:https://www.mdpi.com/2072-6694/15/12/3221

Internet

https://www.mdpi.com/2072-6694/15/12/3221

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