Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer

Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer

Although immune checkpoint inhibitors improved the clinical outcomes of advanced triple negative breast cancer (TBNC) patients, the response rate remains relatively low. Nigericin is an antibiotic derived from <i>Streptomyces hydrophobicus</i>. We found that nigericin caused cell death i...

Full description

Bibliographic Details
Main Authors:	Lisha Wu, Shoumin Bai, Jing Huang, Guohui Cui, Qingjian Li, Jingshu Wang, Xin Du, Wenkui Fu, Chuping Li, Wei Wei, Huan Lin, Man-Li Luo
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Series:	Cancers
Subjects:	nigericin immune checkpoint inhibitor pyroptosis anti-tumor immune-response triple-negative breast cancer
Online Access:	https://www.mdpi.com/2072-6694/15/12/3221

Similar Items

Immune landscape and risk prediction based on pyroptosis-related molecular subtypes in triple-negative breast cancer
by: Lixi Luo, et al.
Published: (2022-09-01)

Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis
by: Pavel I. Deryabin, et al.
Published: (2022-11-01)

The Ionophores CCCP and Gramicidin but Not Nigericin Inhibit <i>Trypanosoma brucei</i> Aquaglyceroporins at Neutral pH
by: Lea Madlen Petersen, et al.
Published: (2020-10-01)

Identification of the pyroptosis-related prognostic gene signature and characterization of tumor microenvironment infiltration in triple-negative breast cancer
by: Ji Liu, et al.
Published: (2022-08-01)

Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages
by: Heather Armstrong, et al.
Published: (2019-10-01)

Annexin A1 Regulates NLRP3 Inflammasome Activation and Modifies Lipid Release Profile in Isolated Peritoneal Macrophages
by: José Marcos Sanches, et al.
Published: (2020-04-01)

Nigericin attenuates lipopolysaccharides induced sepsis and alleviates acute lung injury in in vivo model
by: Longchuan Wu, et al.
Published: (2023-08-01)

The role of pyroptosis in modulating the tumor immune microenvironment
by: Jinxiang Wu, et al.
Published: (2022-06-01)

A pyroptosis‐related signature predicts prognosis and indicates immune microenvironment infiltration in glioma
by: Jia Chen, et al.
Published: (2023-02-01)

Self-assembled albumin nanoparticles induce pyroptosis for photodynamic/photothermal/immuno synergistic therapies in triple-negative breast cancer
by: Jianquan Yang, et al.
Published: (2023-05-01)

Progress of Immunotherapy and Its Application in Triple Negative Breast Cancer
by: ZHENG Hongmei, et al.
Published: (2020-11-01)

Molecular Screening for Nigericin Treatment in Pancreatic Cancer by High-Throughput RNA Sequencing
by: Zhihua Xu, et al.
Published: (2020-07-01)

High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer
by: Zhihua Xu, et al.
Published: (2019-09-01)

Maackiain, a compound derived from Sophora flavescens, increases IL‐1β production by amplifying nigericin‐mediated inflammasome activation
by: Jin‐Won Huh, et al.
Published: (2020-08-01)

The signature of pyroptosis-related gene prognostic and immune microenvironment in adrenocortical carcinoma
by: Jun Gao, et al.
Published: (2023-02-01)

Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in <i>Streptomyces malaysiensis</i> F913
by: Junhong Wei, et al.
Published: (2022-07-01)

Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis
by: Hua Huang, et al.
Published: (2022-03-01)

A pyroptosis-related gene signature predicts prognosis and immune microenvironment in hepatocellular carcinoma
by: Yifeng Jin, et al.
Published: (2022-06-01)

The Pyroptosis-Related Signature Composed of GSDMC Predicts Prognosis and Contributes to Growth and Metastasis of Hepatocellular Carcinoma
by: Min Li, et al.
Published: (2023-10-01)

Immunotherapy for Triple-Negative Breast Cancer: Combination Strategies to Improve Outcome
by: Liying Li, et al.
Published: (2023-01-01)

Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma
by: Susu Zheng, et al.
Published: (2021-12-01)

A novel pyroptosis-related prognostic signature for lung adenocarcinoma: Identification and multi-angle verification
by: Xinyue Wang, et al.
Published: (2023-04-01)

Current Treatment Landscape for Early Triple-Negative Breast Cancer (TNBC)
by: Jieun Lee
Published: (2023-02-01)

Pyroptosis-related gene expression patterns and corresponding tumor microenvironment infiltration characterization in ovarian cancer
by: Jinhui Liu, et al.
Published: (2022-01-01)

Immunotherapy for triple-negative breast cancer: A molecular insight into the microenvironment, treatment, and resistance
by: Xupeng Bai, et al.
Published: (2021-09-01)

Enhanced Production and Quantitative Evaluation of Nigericin from the Algerian Soil-Living <i>Streptomyces youssoufiensis</i> SF10 Strain
by: Nassima Leulmi, et al.
Published: (2019-01-01)

Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies
by: Wuyin Wang, et al.
Published: (2022-07-01)

Advances in immunotherapy for triple-negative breast cancer
by: Yang Liu, et al.
Published: (2023-09-01)

Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer
by: Alyssa Vito, et al.
Published: (2021-05-01)

Potential Predictive and Prognostic Value of Biomarkers Related to Immune Checkpoint Inhibitor Therapy of Triple-Negative Breast Cancer
by: Qiaorui Tan, et al.
Published: (2022-04-01)

Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer
by: JianBin Wu, et al.
Published: (2021-09-01)

Immune checkpoint inhibition in the treatment of early stage triple negative breast cancer: 2021 update
by: Lauren C. Brown, et al.
Published: (2022-03-01)

Cyclin-Dependent Kinase Inhibitors Function as Potential Immune Regulators via Inducing Pyroptosis in Triple Negative Breast Cancer
by: Tao Xu, et al.
Published: (2022-06-01)

A Machine Learning Model to Predict the Triple Negative Breast Cancer Immune Subtype
by: Zihao Chen, et al.
Published: (2021-09-01)

Current treatment landscape for patients with locally recurrent inoperable or metastatic triple-negative breast cancer: a systematic literature review
by: Claire H. Li, et al.
Published: (2019-12-01)

A novel signature based on pyroptosis-related genes for predicting prognosis and treatment response in prostate cancer patients
by: Xi Xiao, et al.
Published: (2022-10-01)

Identification of Key Pyroptosis-Related Genes and Distinct Pyroptosis-Related Clusters in Periodontitis
by: Wanchen Ning, et al.
Published: (2022-06-01)

Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma
by: Yan Zhang, et al.
Published: (2021-12-01)

Hope and Hype around Immunotherapy in Triple-Negative Breast Cancer
by: Flavia Jacobs, et al.
Published: (2023-05-01)

Abscopal Effect of Radiotherapy Enhanced with Immune Checkpoint Inhibitors of Triple Negative Breast Cancer in 4T1 Mammary Carcinoma Model
by: Haa-Na Song, et al.
Published: (2021-09-01)