A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation

A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation

Evidence suggests that the growth and therapeutic resistance of glioblastoma (GBM) may be enabled by a population of glioma stem cells (GSCs) that are regulated by typical stem cell pathways, including the WNT/β-catenin signaling pathway. We wanted to explore the effect of treating GSCs with a small...

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Bibliographic Details
Main Authors: Kirsten Strømme Kierulf-Vieira, Cecilie Jonsgar Sandberg, Jo Waaler, Kaja Lund, Erlend Skaga, Birthe Mikkelsen Saberniak, Ioannis Panagopoulos, Petter Brandal, Stefan Krauss, Iver Arne Langmoen, Einar Osland Vik-Mo
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
glioblastoma
glioma stem cells
tankyrase
temozolomide
β-catenin
WNT
Online Access:https://www.mdpi.com/2072-6694/12/6/1630

Internet

https://www.mdpi.com/2072-6694/12/6/1630

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