Improved Peripheral and Hepatic Insulin Sensitivity after Lifestyle Interventions in Type 2 Diabetes Is Associated with Specific Metabolomic and Lipidomic Signatures in Skeletal Muscle and Plasma

Improved Peripheral and Hepatic Insulin Sensitivity after Lifestyle Interventions in Type 2 Diabetes Is Associated with Specific Metabolomic and Lipidomic Signatures in Skeletal Muscle and Plasma

Lifestyle interventions with weight loss can improve insulin sensitivity in type 2 diabetes (T2D), but mechanisms are unclear. We explored circulating and skeletal muscle metabolite signatures of altered peripheral (pIS) and hepatic insulin sensitivity (hIS) in overweight and obese T2D individuals t...

Full description

Bibliographic Details
Main Authors: Elin Chorell, Julia Otten, Andreas Stomby, Mats Ryberg, Maria Waling, Jon Hauksson, Michael Svensson, Tommy Olsson
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Metabolites
Subjects:
exercise training
diet
type 2 diabetes
hepatic insulin sensitivity (hIS)
peripheral insulin sensitivity (pIS)
skeletal muscle
Online Access:https://www.mdpi.com/2218-1989/11/12/834

Internet

https://www.mdpi.com/2218-1989/11/12/834

Similar Items