Differential Anti-Proliferative and Anti-Migratory Activities of Ursolic Acid, 3-<i>O</i>-Acetylursolic Acid and Their Combination Treatments with Quercetin on Melanoma Cells

Differential Anti-Proliferative and Anti-Migratory Activities of Ursolic Acid, 3-<i>O</i>-Acetylursolic Acid and Their Combination Treatments with Quercetin on Melanoma Cells

We evaluate how 3-acetylation modulates the in vitro activity of ursolic acid in melanoma cells alone or in combination treatments with quercetin. Anti-proliferative studies on A375 cells and adult human dermal fibroblasts included analyses on cell cycle distribution, caspase activity, phosphatidyls...

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Bibliographic Details
Main Authors: Aljawharah AlQathama, Luying Shao, Ammar Bader, Proma Khondkar, Simon Gibbons, Jose M Prieto
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomolecules
Subjects:
pentacyclic triterpenes
apoptosis
melanoma
migration
cell cycle
synergism
Online Access:https://www.mdpi.com/2218-273X/10/6/894

Internet

https://www.mdpi.com/2218-273X/10/6/894

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