A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease

A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease

BackgroundDiffuse midline glioma (DMG) is an aggressive pediatric central nervous system tumor with strong metastatic potential. As localized treatment of the primary tumor improves, metastatic disease is becoming a more important factor in treatment. We hypothesized that we could model craniospinal...

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Bibliographic Details
Main Authors: Aaron J. Knox, Benjamin Van Court, Ayman Oweida, Elinor Barsh, John DeSisto, Patrick Flannery, Rakeb Lemma, Hannah Chatwin, Rajeev Vibhakar, Kathleen Dorris, Natalie J. Serkova, Sana D. Karam, Ahmed Gilani, Adam L. Green
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
diffuse midline glioma
craniospinal irradiation
patient-derived xenograft
metastatic disease
pediatric
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1105395/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1105395/full

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