Integrin-Linked Kinase Expression in Human Valve Endothelial Cells Plays a Protective Role in Calcific Aortic Valve Disease

Integrin-Linked Kinase Expression in Human Valve Endothelial Cells Plays a Protective Role in Calcific Aortic Valve Disease

Calcific aortic valve disease (CAVD) is highly prevalent during aging. CAVD initiates with endothelial dysfunction, leading to lipid accumulation, inflammation, and osteogenic transformation. Integrin-linked kinase (ILK) participates in the progression of cardiovascular diseases, such as endothelial...

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Bibliographic Details
Main Authors: Sandra Sánchez-Esteban, Mercedes Castro-Pinto, Alberto Cook-Calvete, Paula Reventún, María Delgado-Marín, Lucía Benito-Manzanaro, Ignacio Hernandez, José López-Menendez, José Luis Zamorano, Carlos Zaragoza, Marta Saura
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
ILK
nitric oxide
EndMT
calcific valve disease
endothelial dysfunction
aging
Online Access:https://www.mdpi.com/2076-3921/11/9/1736

Internet

https://www.mdpi.com/2076-3921/11/9/1736

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