Computational exploration of molecular flexibility and interaction of meropenem analogs with the active site of oxacillinase-23 in Acinetobacter baumannii

Computational exploration of molecular flexibility and interaction of meropenem analogs with the active site of oxacillinase-23 in Acinetobacter baumannii

Background: Carbapenem-resistant Acinetobacter baumannii is an opportunistic pathogen responsible for nosocomial infections and is one of the biggest global threats according to the World Health Organization (WHO), particularly causing substantial morbidity and mortality.Objectives: This study aimed...

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Bibliographic Details
Main Authors: Balajee Ramachandran, Saravanan Muthupandian, Jeyakanthan Jeyaraman, Bruno Silvester Lopes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Chemistry
Subjects:
Acinetobacter baumannii
beta-lactamases
oxacillinase
OXA-23
OXA-23 variants
meropenem
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1090630/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2023.1090630/full

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