Intrinsic indicator of photodamage during label-free multiphoton microscopy of cells and tissues.

Multiphoton imaging has evolved as an indispensable tool in cell biology and holds prospects for clinical applications. When addressing endogenous signals such as coherent anti-Stokes Raman scattering (CARS) or second harmonic generation, it requires intense laser irradiation that may cause photodam...

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Bibliographic Details
Main Authors: Roberta Galli, Ortrud Uckermann, Elisabeth F Andresen, Kathrin D Geiger, Edmund Koch, Gabriele Schackert, Gerald Steiner, Matthias Kirsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0110295