ALDH1A3 Accelerates Pancreatic Cancer Metastasis by Promoting Glucose Metabolism

ALDH1A3 Accelerates Pancreatic Cancer Metastasis by Promoting Glucose Metabolism

Background: The aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is a key enzyme associated with a variety of metabolic processes, including glucose metabolism. We recently uncovered that glucose metabolism played an essential role in promoting metastasis of pancreatic ductal adenocarcinoma (PDAC...

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Bibliographic Details
Main Authors: Shuang Nie, Xuetian Qian, Mengyue Shi, Hongzhen Li, Chunyan Peng, Xiwei Ding, Shu Zhang, Bin Zhang, Guifang Xu, Ying Lv, Lei Wang, Helmut Friess, Bo Kong, Xiaoping Zou, Shanshan Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
pancreatic ductal adenocarcinoma
ALDH1A3
PPARγ
HK2
tumor metastasis
glycolysis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00915/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00915/full

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