Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: statistical evaluation of epistasis.

Understanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the joint effect of two loci on rs4242382 at 8q24 and rs10486567 at 7p15.2 to this...

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Main Authors: Li-Sheng Chen, Jean Ching-Yuan Fann, Sherry Yueh-Hsia Chiu, Amy Ming-Fang Yen, Tiina Wahlfors, Teuvo L Tammela, Hsiu-Hsi Chen, Anssi Auvinen, Johanna Schleutker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089508&type=printable