Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

Sterol regulatory element-binding protein (SREBP) transcription factors are central regulators of cellular lipid homeostasis and activate expression of genes required for fatty acid, triglyceride, and cholesterol synthesis and uptake. SREBP cleavage activating protein (SCAP) plays an essential role...

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Bibliographic Details
Main Authors: Wei Shao (邵威), Carolyn E. Machamer, Peter J. Espenshade
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Lipid Research
Subjects:
sterol regulatory element-binding protein cleavage activating protein
sterol regulatory element-binding protein
endoplasmic reticulum-to-Golgi transport
endoplasmic reticulum
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352263

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http://www.sciencedirect.com/science/article/pii/S0022227520352263

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