Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer

Abstract As a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, Fluvastatin (FLV) is used for reducing low-density lipoprotein (LDL) cholesterol as well as to prevent cardiovascular problems. FLV showed cell line cytotoxicity and antitumor effect. Melittin (MEL) exhibits antineoplastic...

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Bibliographic Details
Main Authors: Mohamed A. Alfaleh, Omar Fahmy, Mohammed W. Al-Rabia, Mohammed A. S. Abourehab, Osama A. A. Ahmed, Usama A. Fahmy, Helal H. Alsulimani, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Bander M. Aldhabi, Awaad S. Alharbi, Nabil A. Alhakamy
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24151-3