A methylated lysine is a switch point for conformational communication in the chaperone Hsp90

A methylated lysine is a switch point for conformational communication in the chaperone Hsp90

Methylation of a lysine residue in Hsp90 is a recently discovered post-translational modification but the mechanistic effects of this modification have remained unknown so far. Here the authors combine biochemical and biophysical approaches, molecular dynamics (MD) simulations and functional experim...

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Bibliographic Details
Main Authors: Alexandra Rehn, Jannis Lawatscheck, Marie-Lena Jokisch, Sophie L. Mader, Qi Luo, Franziska Tippel, Birgit Blank, Klaus Richter, Kathrin Lang, Ville R. I. Kaila, Johannes Buchner
Format: Article
Language:English
Published: Nature Portfolio 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15048-8

Internet

https://doi.org/10.1038/s41467-020-15048-8

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