Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway

Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway

Platelet-derived growth factor-BB (PDGF-BB) is a cytokine involved in tissue repair and tumor progression. It has been found to have expression differences between normal and degenerative intervertebral discs. However, it is not clear whether PDGF-BB has a protective effect on intervertebral disc de...

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Bibliographic Details
Main Authors: Weikang Zhang, Yuhang Gong, Xiaohang Zheng, Jianxin Qiu, Ting Jiang, Lihua Chen, Fangying Lu, Xinhui Wu, Fengmin Cheng, Zhenghua Hong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
degeneration
pyroptosis
extracellular matrix
intervertebral disc
PDGF-BB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.799130/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.799130/full

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