Additive effect of 5-HT2C and CB1 receptor blockade on the regulation of sleep–wake cycle

Abstract Background Previous data show that serotonin 2C (5-HT2C) and cannabinoid 1 (CB1) receptors have a role in the modulation of sleep–wake cycle. Namely, antagonists on these receptors promoted wakefulness and inhibited rapid eye movement sleep (REMS) in rodents. The interaction of these recept...

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Bibliographic Details
Main Authors: Emese Bogáthy, Noémi Papp, Laszló Tóthfalusi, Szilvia Vas, György Bagdy
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Neuroscience
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12868-019-0495-7