Transcriptional Correlates of Tolerance and Lethality in Mice Predict Ebola Virus Disease Patient Outcomes

Transcriptional Correlates of Tolerance and Lethality in Mice Predict Ebola Virus Disease Patient Outcomes

Summary: Host response to infection is a major determinant of disease severity in Ebola virus disease (EVD), but gene expression programs associated with outcome are poorly characterized. Collaborative Cross (CC) mice develop strain-dependent EVD phenotypes of differential severity, ranging from tol...

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Bibliographic Details
Main Authors: Adam Price, Atsushi Okumura, Elaine Haddock, Friederike Feldmann, Kimberly Meade-White, Pryanka Sharma, Methinee Artami, W. Ian Lipkin, David W. Threadgill, Heinz Feldmann, Angela L. Rasmussen
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720300358

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http://www.sciencedirect.com/science/article/pii/S2211124720300358

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