PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model

Abstract Background Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache responses in preclinical models. It is also well known that vasodilators such a...

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Bibliographic Details
Main Authors: Bianca N. Mason, Shayne N. Hassler, Kathryn DeFea, Scott Boitano, Josef Vagner, Theodore J. Price, Greg Dussor
Format: Article
Language:English
Published: BMC 2023-04-01
Series:The Journal of Headache and Pain
Subjects:
Online Access:https://doi.org/10.1186/s10194-023-01574-5