Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/β-catenin cascade

Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/β-catenin cascade

Abstract Background Pathological cardiac hypertrophy is associated with cardiac dysfunction and is a key risk factor for heart failure and even sudden death. This study investigates the function of Mycn in cardiac hypertrophy and explores the interacting molecules. Methods A mouse model of cardiac h...

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Bibliographic Details
Main Authors: Weinian Gao, Na Guo, Hongjiang Yan, Shuguang Zhao, Yongquan Sun, Ziying Chen
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Cardiovascular Disorders
Subjects:
Cardiac hypertrophy
Heart failure
Mycn
USP2
JUP
Akt/β-catenin
Online Access:https://doi.org/10.1186/s12872-024-03748-8

Internet

https://doi.org/10.1186/s12872-024-03748-8

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