IgM cleavage by Streptococcus suis reduces IgM bound to the bacterial surface and is a novel complement evasion mechanism

IgM cleavage by Streptococcus suis reduces IgM bound to the bacterial surface and is a novel complement evasion mechanism

Streptococcus suis (S. suis) causes meningitis, arthritis and endocarditis in piglets. The aim of this study was to characterize the IgM degrading enzyme of S. suis (IdeSsuis) and to investigate the role of IgM cleavage in evasion of the classical complement pathway and pathogenesis. Targeted mutage...

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Bibliographic Details
Main Authors: Viktoria Rungelrath, Christine Weiße, Nicole Schütze, Uwe Müller, Marita Meurer, Manfred Rohde, Jana Seele, Peter Valentin-Weigand, Michael Kirschfink, Andreas Beineke, Wieland Schrödl, René Bergmann, Christoph Georg Baums
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
Streptococcus suis
IdeSsuis
IgM
opsonization
cysteine protease
IdeS-family protease
Online Access:http://dx.doi.org/10.1080/21505594.2018.1496778

Internet

http://dx.doi.org/10.1080/21505594.2018.1496778

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