Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer
Blockade of EGFR with reversible EGFR tyrosine kinase inhibitors (TKIs) is considered the frontline strategy for advanced NSCLC with EGFR mutations. However, acquired resistance to EGFR-TKI has been observed, resulting in disease progression and limited clinical benefit. Polyphyllin VII is the main...
Главные авторы: | , , |
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Формат: | Статья |
Язык: | English |
Опубликовано: |
Elsevier
2017-07-01
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Серии: | Journal of Pharmacological Sciences |
Предметы: | |
Online-ссылка: | http://www.sciencedirect.com/science/article/pii/S1347861317300919 |