Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer

Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer

Blockade of EGFR with reversible EGFR tyrosine kinase inhibitors (TKIs) is considered the frontline strategy for advanced NSCLC with EGFR mutations. However, acquired resistance to EGFR-TKI has been observed, resulting in disease progression and limited clinical benefit. Polyphyllin VII is the main...

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Bibliographic Details
Main Authors: Honggang Wang, Zhenghua Fei, Hao Jiang
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Pharmacological Sciences
Subjects:
P21
Acquired resistance
NSCLC
Polyphyllin
Cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300919

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http://www.sciencedirect.com/science/article/pii/S1347861317300919

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