Intracellular Survival of Leishmania major Depends on Uptake and Degradation of Extracellular Matrix Glycosaminoglycans by Macrophages.

Leishmania parasites replicate within the phagolysosome compartment of mammalian macrophages. Although Leishmania depend on sugars as a major carbon source during infections, the nutrient composition of the phagolysosome remains poorly described. To determine the origin of the sugar carbon source in...

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Bibliographic Details
Main Authors: Thomas Naderer, Joanne Heng, Eleanor C Saunders, Joachim Kloehn, Thusitha W Rupasinghe, Tracey J Brown, Malcolm J McConville
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4559419?pdf=render