From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome

From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome

Lynch syndrome is a hereditary cancer-predisposing syndrome caused by germline defects in DNA mismatch repair (MMR) genes such as <i>MLH1</i>, <i>MSH2</i>, <i>MSH6</i>, and <i>PMS2</i>. Carriers of pathogenic mutations in these genes have an increased...

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Bibliographic Details
Main Authors: Martina Lepore Signorile, Vittoria Disciglio, Gabriella Di Carlo, Antonio Pisani, Cristiano Simone, Giuseppe Ingravallo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Lynch syndrome
CRC
early detection
MMR genes
Online Access:https://www.mdpi.com/1422-0067/22/13/6767

Internet

https://www.mdpi.com/1422-0067/22/13/6767

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