DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells

DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells

Abstract Epithelial barrier dysfunction and crypt destruction are hallmarks of inflammatory bowel disease (IBD). Intestinal stem cells (ISCs) residing in the crypts play a crucial role in the continuous self-renewal and rapid recovery of intestinal epithelial cells (IECs). However, how ISCs are dysr...

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Bibliographic Details
Main Authors: Xingxing Ren, Qiuyuan Liu, Peirong Zhou, Tingyue Zhou, Decai Wang, Qiao Mei, Richard A. Flavell, Zhanju Liu, Mingsong Li, Wen Pan, Shu Zhu
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47235-2

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https://doi.org/10.1038/s41467-024-47235-2

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