Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology

Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology

Spinal muscular atrophy (SMA) is caused by mutations in the Survival Motor Neuron 1 (SMN1) gene. While traditionally viewed as a motor neuron disorder, there is involvement of various peripheral organs in SMA. Notably, fatty liver has been observed in SMA mouse models and SMA patients. Nevertheless,...

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Bibliographic Details
Main Authors: Monique Marylin Alves de Almeida, Yves De Repentigny, Sabrina Gagnon, Emma R Sutton, Rashmi Kothary
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
Mouse
metabolism
pancreas
neuromuscular disease
Online Access:https://elifesciences.org/articles/99141

Internet

https://elifesciences.org/articles/99141

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