MST1 deletion protects β-cells in a mouse model of diabetes

Abstract The pro-apoptotic kinase Mammalian Sterile 20-like kinase 1 (MST1), an integral component of the Hippo pathway, is a key regulator of organ size, stress response, and tissue homeostasis; its aberrant hyperactivation is linked to multiple pathological disorders including diabetes. Here we sh...

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Bibliographic Details
Main Authors: Amin Ardestani, Kathrin Maedler
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Nutrition & Diabetes
Online Access:https://doi.org/10.1038/s41387-022-00186-3