The p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis

The p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis

Abstract Background To explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and underlying molecular mechanism. Methods Bioinformatics analyses were performed on transcriptome data of liver tissues from mice and patients with li...

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Bibliographic Details
Main Authors: Yun Feng, Wenhua Li, Zhuoya Wang, Ruling Zhang, Yan Li, Lijuan Zang, Peiwen Wang, Zhenghong Li, Yuwei Dong
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Translational Medicine
Subjects:
p-STAT3
ANXA2
Caspase-1
Pyroptosis
NASH
Hepatic fibrosis
Online Access:https://doi.org/10.1186/s12967-022-03692-1

Internet

https://doi.org/10.1186/s12967-022-03692-1

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