A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed rats
Abstract Background Consumption of refined carbohydrates has risen in recent years alongside chronic diseases such as type 2 diabetes mellitus, dyslipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD). Fructose is a monosaccharide made widely available in industrialized products, capable...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2020-09-01
|
| Series: | Egyptian Liver Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43066-020-00045-9 |
| _version_ | 1818926827735875584 |
|---|---|
| author | Gabriel Perri Esteves Camila Sanches Manca Hellen Paraguassú Veida-Silva Paula Payão Ovidio Héric Holland Flávia Sayuri Matsuo Mariana Kiomy Osako Alceu Afonso Jordao |
| author_facet | Gabriel Perri Esteves Camila Sanches Manca Hellen Paraguassú Veida-Silva Paula Payão Ovidio Héric Holland Flávia Sayuri Matsuo Mariana Kiomy Osako Alceu Afonso Jordao |
| author_sort | Gabriel Perri Esteves |
| collection | DOAJ |
| description | Abstract Background Consumption of refined carbohydrates has risen in recent years alongside chronic diseases such as type 2 diabetes mellitus, dyslipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD). Fructose is a monosaccharide made widely available in industrialized products, capable of inducing excessive weight gain and liver steatosis in animal models, while omega-3 fatty acids, present in foods such as fatty fish and fish oil, have shown to inhibit genes related to lipogenesis and decrease cardiovascular risk. Therefore, our objective was to evaluate the impact of a high-fructose diet on weight gain, biochemical and oxidative stress parameters, and liver histology and investigate fish oil’s potential protective role. Thirty male Wistar rats were divided into 3 groups: regular chow diet (CT), regular chow diet plus 20% fructose in drinking water (Fr), and a diet containing 10% fish oil plus 20% fructose in drinking water (FOFr). After 12 weeks, tissues of interest were collected for biochemical and histological analyses. Results Although fructose consumption did not lead to increased hepatic fat, it caused a significant increase in weight gain, white adipose tissue, and serum triglycerides in the Fr group, while fish oil promoted normalized serum triglycerides and even reduced adiposity in the FOFr group. Additionally, the inclusion of fish oil in the FOFr diet led to increased liver lipid peroxidation in the form of increased hepatic MDA. Conclusions It is concluded that fish oil can prevent important metabolic alterations caused by fructose consumption, but its dosage must be taken into account to prevent oxidative stress and potential liver damage. |
| first_indexed | 2024-12-20T03:03:19Z |
| format | Article |
| id | doaj.art-e5ad50b15a084c1e8a5b45d3ffd74894 |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-12-20T03:03:19Z |
| publishDate | 2020-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-e5ad50b15a084c1e8a5b45d3ffd748942022-12-21T19:55:41ZengSpringerOpenEgyptian Liver Journal2090-62262020-09-011011910.1186/s43066-020-00045-9A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed ratsGabriel Perri Esteves0Camila Sanches Manca1Hellen Paraguassú Veida-Silva2Paula Payão Ovidio3Héric Holland4Flávia Sayuri Matsuo5Mariana Kiomy Osako6Alceu Afonso Jordao7Department of Health Sciences, Ribeirao Preto Medical School, University of Sao PauloDepartment of Health Sciences, Ribeirao Preto Medical School, University of Sao PauloDepartment of Physiology, Ribeirao Preto Medical School, University of Sao PauloDepartment of Health Sciences, Ribeirao Preto Medical School, University of Sao PauloDepartment of Health Sciences, Ribeirao Preto Medical School, University of Sao PauloDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirao Preto Medical School, University of Sao PauloDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirao Preto Medical School, University of Sao PauloDepartment of Health Sciences, Ribeirao Preto Medical School, University of Sao PauloAbstract Background Consumption of refined carbohydrates has risen in recent years alongside chronic diseases such as type 2 diabetes mellitus, dyslipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD). Fructose is a monosaccharide made widely available in industrialized products, capable of inducing excessive weight gain and liver steatosis in animal models, while omega-3 fatty acids, present in foods such as fatty fish and fish oil, have shown to inhibit genes related to lipogenesis and decrease cardiovascular risk. Therefore, our objective was to evaluate the impact of a high-fructose diet on weight gain, biochemical and oxidative stress parameters, and liver histology and investigate fish oil’s potential protective role. Thirty male Wistar rats were divided into 3 groups: regular chow diet (CT), regular chow diet plus 20% fructose in drinking water (Fr), and a diet containing 10% fish oil plus 20% fructose in drinking water (FOFr). After 12 weeks, tissues of interest were collected for biochemical and histological analyses. Results Although fructose consumption did not lead to increased hepatic fat, it caused a significant increase in weight gain, white adipose tissue, and serum triglycerides in the Fr group, while fish oil promoted normalized serum triglycerides and even reduced adiposity in the FOFr group. Additionally, the inclusion of fish oil in the FOFr diet led to increased liver lipid peroxidation in the form of increased hepatic MDA. Conclusions It is concluded that fish oil can prevent important metabolic alterations caused by fructose consumption, but its dosage must be taken into account to prevent oxidative stress and potential liver damage.http://link.springer.com/article/10.1186/s43066-020-00045-9Oxidative stressLipid peroxidationOmega-3 fatty acidsFish oilNAFLDFructose |
| spellingShingle | Gabriel Perri Esteves Camila Sanches Manca Hellen Paraguassú Veida-Silva Paula Payão Ovidio Héric Holland Flávia Sayuri Matsuo Mariana Kiomy Osako Alceu Afonso Jordao A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed rats Egyptian Liver Journal Oxidative stress Lipid peroxidation Omega-3 fatty acids Fish oil NAFLD Fructose |
| title | A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed rats |
| title_full | A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed rats |
| title_fullStr | A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed rats |
| title_full_unstemmed | A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed rats |
| title_short | A fish oil-rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose-fed rats |
| title_sort | fish oil rich diet leads to lower adiposity and serum triglycerides but increases liver lipid peroxidation in fructose fed rats |
| topic | Oxidative stress Lipid peroxidation Omega-3 fatty acids Fish oil NAFLD Fructose |
| url | http://link.springer.com/article/10.1186/s43066-020-00045-9 |
| work_keys_str_mv | AT gabrielperriesteves afishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT camilasanchesmanca afishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT hellenparaguassuveidasilva afishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT paulapayaoovidio afishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT hericholland afishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT flaviasayurimatsuo afishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT marianakiomyosako afishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT alceuafonsojordao afishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT gabrielperriesteves fishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT camilasanchesmanca fishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT hellenparaguassuveidasilva fishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT paulapayaoovidio fishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT hericholland fishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT flaviasayurimatsuo fishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT marianakiomyosako fishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats AT alceuafonsojordao fishoilrichdietleadstoloweradiposityandserumtriglyceridesbutincreasesliverlipidperoxidationinfructosefedrats |