Pharmacological Inhibition of Sonic Hedgehog Signaling Suppresses Tumor Development in a Murine Model of Intrahepatic Cholangiocarcinoma

Pharmacological Inhibition of Sonic Hedgehog Signaling Suppresses Tumor Development in a Murine Model of Intrahepatic Cholangiocarcinoma

Cholangiocarcinoma (CCC) is the second most primary liver cancer with an aggressive biological behavior, and its incidence increases steadily. An aberrant up-regulation of the sonic hedgehog signaling pathway has been reported in a variety of hepatic diseases including hepatic inflammation, fibrosis...

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Bibliographic Details
Main Authors: Kyungjoo Cho, Hyuk Moon, Sang Hyun Seo, Simon Weonsang Ro, Beom Kyung Kim
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
cholangiocarcinoma
hydrodynamic transfection
sonic hedgehog
hedgehog pathway inhibitor
molecular target therapy
Online Access:https://www.mdpi.com/1422-0067/22/24/13214

Internet

https://www.mdpi.com/1422-0067/22/24/13214

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