Jolkinolide B induces reactive oxygen species accumulation and endoplasmic reticulum stress and inhibits MAPK and AKT signaling activation in renal cancer cells

Jolkinolide B induces reactive oxygen species accumulation and endoplasmic reticulum stress and inhibits MAPK and AKT signaling activation in renal cancer cells

To investigate the impact of Jolkinolide B (JB) on renal cell carcinoma (RCC), we treated RCC cell lines with various concentrations of JB (0, 5, 25, 50 and 100 μM) for 24 hours and assessed cell viability using the cell counting kit-8 (CCK-8) analysis. Then, we examined JB’s effects on prolifera...

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Bibliographic Details
Main Authors: Xuan Wu, Sijing Pan, Xiujuan Li, Jing Liu, Zhigang Wang, Yinghong Lei, Qunchao Mei
Format: Article
Language:English
Published: MRE Press 2024-05-01
Series:Journal of Men's Health
Subjects:
renal cancer
jolkinolide b
ros
endoplasmic reticulum stress
mapk
akt
Online Access:https://oss.jomh.org/files/article/20240530-282/pdf/JOMH2024031501.pdf

Internet

https://oss.jomh.org/files/article/20240530-282/pdf/JOMH2024031501.pdf

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