NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction
In type 2 diabetes, metabolic stress has a negative impact on pancreatic β-cell function and survival (T2D). Although the pathogenesis of metabolic stress is complex, an imbalance in redox homeostasis causes abnormal tissue damage and β-cell death due to low endogenous antioxidant expression levels...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/7/1573 |
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| author | Suma Elumalai Udayakumar Karunakaran Jun-Sung Moon Kyu-Chang Won |
| author_facet | Suma Elumalai Udayakumar Karunakaran Jun-Sung Moon Kyu-Chang Won |
| author_sort | Suma Elumalai |
| collection | DOAJ |
| description | In type 2 diabetes, metabolic stress has a negative impact on pancreatic β-cell function and survival (T2D). Although the pathogenesis of metabolic stress is complex, an imbalance in redox homeostasis causes abnormal tissue damage and β-cell death due to low endogenous antioxidant expression levels in β-cells. Under diabetogenic conditions, the susceptibility of β-cells to oxidative damage by NADPH oxidase has been related to contributing to β-cell dysfunction. Here, we consider recent insights into how the redox response becomes deregulated under diabetic conditions by NADPH oxidase, as well as the therapeutic benefits of NOX inhibitors, which may provide clues for understanding the pathomechanisms and developing strategies aimed at the treatment or prevention of metabolic stress associated with β-cell failure. |
| first_indexed | 2024-03-10T10:11:11Z |
| format | Article |
| id | doaj.art-e5b1d05825d14d31a8928df658589412 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:11:11Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e5b1d05825d14d31a8928df6585894122023-11-22T01:14:02ZengMDPI AGCells2073-44092021-06-01107157310.3390/cells10071573NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell DysfunctionSuma Elumalai0Udayakumar Karunakaran1Jun-Sung Moon2Kyu-Chang Won3Innovative Center for Aging Research, Yeungnam University Medical Center, Daegu 42415, KoreaInnovative Center for Aging Research, Yeungnam University Medical Center, Daegu 42415, KoreaInnovative Center for Aging Research, Yeungnam University Medical Center, Daegu 42415, KoreaInnovative Center for Aging Research, Yeungnam University Medical Center, Daegu 42415, KoreaIn type 2 diabetes, metabolic stress has a negative impact on pancreatic β-cell function and survival (T2D). Although the pathogenesis of metabolic stress is complex, an imbalance in redox homeostasis causes abnormal tissue damage and β-cell death due to low endogenous antioxidant expression levels in β-cells. Under diabetogenic conditions, the susceptibility of β-cells to oxidative damage by NADPH oxidase has been related to contributing to β-cell dysfunction. Here, we consider recent insights into how the redox response becomes deregulated under diabetic conditions by NADPH oxidase, as well as the therapeutic benefits of NOX inhibitors, which may provide clues for understanding the pathomechanisms and developing strategies aimed at the treatment or prevention of metabolic stress associated with β-cell failure.https://www.mdpi.com/2073-4409/10/7/1573NADPH oxidasediabetes mellitusinsulin-secreting cellsoxidative stressreactive oxygen species |
| spellingShingle | Suma Elumalai Udayakumar Karunakaran Jun-Sung Moon Kyu-Chang Won NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction Cells NADPH oxidase diabetes mellitus insulin-secreting cells oxidative stress reactive oxygen species |
| title | NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction |
| title_full | NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction |
| title_fullStr | NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction |
| title_full_unstemmed | NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction |
| title_short | NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction |
| title_sort | nadph oxidase nox targeting in diabetes a special emphasis on pancreatic β cell dysfunction |
| topic | NADPH oxidase diabetes mellitus insulin-secreting cells oxidative stress reactive oxygen species |
| url | https://www.mdpi.com/2073-4409/10/7/1573 |
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