Time series clustering of T cell subsets dissects heterogeneity in immune reconstitution and clinical outcomes among MUD-HCT patients receiving ATG or PTCy

Time series clustering of T cell subsets dissects heterogeneity in immune reconstitution and clinical outcomes among MUD-HCT patients receiving ATG or PTCy

IntroductionAnti-T-lymphocyte globulin (ATG) or post-transplant cyclophosphamide (PTCy) prevent graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT), yet individual patients benefit differentially.MethodsGiven the sparse comparative data on the impact of cellular immune re...

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Bibliographic Details
Main Authors: Saskia Leserer, Theresa Graf, Martina Franke, Rashit Bogdanov, Esteban Arrieta-Bolaños, Ulrike Buttkereit, Nils Leimkühler, Katharina Fleischhauer, Hans Christian Reinhardt, Dietrich W. Beelen, Amin T. Turki
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
GVHD prophylaxis
anti-thymocyte globulin (ATG)
post-transplant cyclophosphamide
unsupervised learning
matched unrelated donor allogeneic hematopoietic stem cell transplantation
anti-T-lymphocyte globulin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1082727/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1082727/full

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